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stratum corneum of esophageal epithelium #3424
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@@ -45,9 +45,6 @@ synonymtypedef: PENDING_REVIEW "expert consultation and attribution required" | |
synonymtypedef: SENSU "taxonomic disambiguation" | ||
synonymtypedef: SYSTEMATIC "a systematic synonym used as the base name for design patterns" | ||
default-namespace: uberon | ||
idspace: EFO http://www.ebi.ac.uk/efo/EFO_ | ||
idspace: NIF_Subcellular http://www.neurolex.org/wiki/ | ||
idspace: NIFEXT http://uri.neuinfo.org/nif/nifstd/nifext_ | ||
treat-xrefs-as-equivalent: AEO | ||
treat-xrefs-as-equivalent: BILA | ||
treat-xrefs-as-equivalent: BSPO | ||
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@@ -72993,8 +72990,8 @@ id: UBERON:0003532 | |
name: hindlimb skin | ||
def: "A zone of skin that is part of a hindlimb [Automatically generated definition]." [OBOL:automatic] | ||
synonym: "hind limb skin" EXACT [OBOL:automatic] | ||
synonym: "lower limb skin" EXACT [https://orcid.org/0000-0002-0819-0473] | ||
synonym: "lower limb skin" EXACT [FMA:23102] | ||
synonym: "lower limb skin" EXACT [https://orcid.org/0000-0002-0819-0473] | ||
synonym: "skin of hind limb" EXACT [OBOL:automatic] | ||
synonym: "skin of hindlimb" EXACT [OBOL:automatic] | ||
synonym: "skin of lower extremity" EXACT [OBOL:automatic] | ||
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@@ -224734,6 +224731,15 @@ relationship: dc-contributor https://orcid.org/0009-0005-7919-4905 | |
relationship: part_of UBERON:0001043 ! esophagus | ||
property_value: dcterms-date "2024-11-14T15:00:21Z" xsd:dateTime | ||
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[Term] | ||
id: UBERON:8700003 | ||
name: stratum corneum of esophageal epithelium | ||
def: "The outermost layer of the stratified squamous epithelium lining the esophagus, composed of several layers of flattened, anucleated keratinocytes called corneocytes. It forms the primary protective barrier against mechanical, chemical, and microbial insults, while regulating permeability and contributing to tissue integrity. This layer is characterized by corneocytes embedded in a lipid-rich extracellular matrix, providing mechanical reinforcement and maintaining essential barrier functions of the esophageal lining." [doi:10.1038/gimo15, PMID:21126700, PMID:26019440] | ||
There was a problem hiding this comment. Choose a reason for hiding this commentThe reason will be displayed to describe this comment to others. Learn more. I would also suggest removing the details about anucleated if there is no supporting evidence specific to the esophagus as I found that the state of the nucleus is not consistent across species. For example, cells in the human esophageal stratum corneum (and other mammals) seem to retain their nuclei, whereas in mice they do not (https://doi.org/10.1152/ajpgi.00088.2015, https://en.wikipedia.org/wiki/Stratified_squamous_epithelium). There was a problem hiding this comment. Choose a reason for hiding this commentThe reason will be displayed to describe this comment to others. Learn more. I would suggest editing the definition a little bit ie.
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is_a: UBERON:0010304 ! non-keratinized stratified squamous epithelium | ||
relationship: dc-contributor https://orcid.org/0009-0005-7919-4905 | ||
relationship: part_of UBERON:0001043 ! esophagus | ||
property_value: dcterms-date "2024-11-14T15:10:48Z" xsd:dateTime | ||
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[Term] | ||
id: UBERON:8850000 | ||
name: lumen of pulmonary alveolus | ||
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I could not find anything in the provided references describing the stratum corneum of esophageal epithelium as containing anucleated keratinocytes (corneocytes). I believe corneocytes are more commonly associated with the keratinized cells of the skin. The esophagus typically has a non-keratinized or partially keratinized stratified squamous epithelium, where the outermost cells retain their nuclei and do not form corneocytes as seen in the skin