Skip to content

Commit

Permalink
Merge pull request #45 from mpxv-lineages/designations-2024-11
Browse files Browse the repository at this point in the history
Designation of 11 new B.1 sublineages
  • Loading branch information
corneliusroemer authored Nov 14, 2024
2 parents d9edebb + 3bb8441 commit 344e537
Show file tree
Hide file tree
Showing 20 changed files with 670 additions and 14 deletions.
31 changes: 19 additions & 12 deletions README.md
Original file line number Diff line number Diff line change
Expand Up @@ -9,19 +9,21 @@ The recent outbreak among humans originated from clade IIb.
## [Lineage summary](auto-generated/lineages.md)

## Designation of lineages

New lineages are designated as more cases are sequenced and the outbreak gets more diverse.
The criteria for lineage designation will evolve as the outbreak continues.
Currently, we aim to designate a new lineage if it

- has spread internationally
- has at least 1 mutation above its parent
- contains at least 15 sequences or plausibly represents undersampled diversity
- has a clear common phylogenetic structure (no uncertainty about possibly being designated as 2 lineages instead of 1)
- has at least one freely available high quality reference sequence (high quality meaning that it doesn't show unusually large numbers of frame shifts and/or stop codons)
- has spread internationally
- has at least 1 mutation above its parent
- contains at least 15 sequences or plausibly represents undersampled diversity
- has a clear common phylogenetic structure (no uncertainty about possibly being designated as 2 lineages instead of 1)
- has at least one freely available high quality reference sequence (high quality meaning that it doesn't show unusually large numbers of frame shifts and/or stop codons)

Each new lineage is defined by a `yaml` file according the [schema](schemas/single_lineage/lineage_schema_1-0-0.yml).
For lineage [B.1](lineages/B.1.yml), for example, this looks like this
```

```yaml
# yaml-language-server: $schema=../schemas/single_lineage/lineage_schema_1-0-0.yml
name: B.1
unaliased_name: A.1.1.1
Expand All @@ -41,11 +43,16 @@ A human readable summary of all designated lineages can be found [here](auto-gen

You can find markdown documents describing the rationale of lineage designation (including which lineages and why) in the "designation_records" folder.

- [2022-08-08: B.1.1-B.1.5](designation_records/B.1.1-B.1.5_2022-08-08.md)
- [2022-08-25: B.1.6-B.1.8](designation_records/B.1.6-B.1.8_2022-08-25.md)
- [2022-09-13: B.1.9-A.2.1](designation_records/B.1.9-A.2.1_2022-09-13.md)
- [2022-09-26: B.1.10-A.2.2](designation_records/B.1.10-A.2.2_2022-09-26.md)
- [2022-08-08: B.1.1-B.1.5](designation_records/B.1.1-B.1.5_2022-08-08.md)
- [2022-08-25: B.1.6-B.1.8](designation_records/B.1.6-B.1.8_2022-08-25.md)
- [2022-09-13: B.1.9-A.2.1](designation_records/B.1.9-A.2.1_2022-09-13.md)
- [2022-09-26: B.1.10-A.2.2](designation_records/B.1.10-A.2.2_2022-09-26.md)
- [2022-10-31: B.1.13-B.1.14-A.2.3-A.3](designation_records/B.1.13-B.1.14-A.2.3-A.3_2022-10-31.md)
- [2023-01-11: B.1.15-B.1.16-B.1.17](designation_records/B.1.15-B.1.16-B.1.17_2023-01-11.md)
- [2023-08-01: B.1.18-B.1.19-B.1.20-C.1](designation_records/B.1.18-B.1.19-B.1.20-C.1_2023-08-01.md)
- [2024-04-15: B.1.21-B.1.22-C.1.1](designation_records/B.1.21-B.1.22-C.1.1_2024-04-15.md)
- [2024-11-05: B.1.23-D.1-E.1-3-F.1-6](designation_records/B.1.23-D.1-E.1-3-F.1-6_2024-11-05.md)

### Lineage proposals
To propose additional lineages, open a github issue in this repository.
## Lineage proposals

To propose additional lineages, open a github issue in this repository.
5 changes: 4 additions & 1 deletion auto-generated/alias_key.json
Original file line number Diff line number Diff line change
@@ -1,5 +1,8 @@
{
"A": "",
"B": "A.1.1",
"C": "A.1.1.1.3"
"C": "A.1.1.1.3",
"D": "A.1.1.1.6",
"E": "A.1.1.1.3.1.1",
"F": "A.1.1.1.20"
}
Loading

0 comments on commit 344e537

Please sign in to comment.