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## Overview

HCV-GLUE is a sequence-oriented resource for comparative genomic analysis of hepatitis C virus (HCV), developed using the [GLUE](https://github.com/giffordlabcvr/gluetools) software framework.
HCV-GLUE is a sequence-oriented resource for comparative genomic analysis of hepatitis C virus (HCV), developed using the [GLUE](https://github.com/giffordlabcvr/gluetools) software framework. It includes a web interface that can be used to create a HCV-GLUE web-server.

HCV-GLUE contains HCV feature definitions, annotated reference sequences for all HCV genotypes and subtypes, and heirarchically ordered multiple sequence alignments.

This **HCV-GLUE** base project can be extended with additional layers, openly availabe via GitHub, including:

- **[NCBI-HCV-GLUE](https://github.com/giffordlabcvr/NCBI-HCV-GLUE)**: extends HCV-GLUE through the incorporation of all HCV sequence data published in NCBI GenBank.
- **[HCV-GLUE-WEB](https://github.com/giffordlabcvr/HCV-GLUE-WEB)**: a web interface that can be used to create a HCV-GLUE web-server.
- **[PHE-HCV-DRUG-RESISTANCE ](https://github.com/giffordlabcvr/PHE-HCV-DRUG-RESISTANCE B)**: a drug resistance-focussed extension incorporating an analysis tool that provides genotypic assessment of drug resistance/susceptibility.

A web instance of HCV-GLUE incorporating both these extension layers is hosted by the University of Glasgow, and can be accessed here **[here](http://hcv-glue.cvr.gla.ac.uk/)**.

In HCV-GLUE, HCV sequence data are richly annotated with gene features and isolate-associated information. HCV-GLUE also contains reference sequences for all HCV genotypes and subtypes, as well as heirarchically ordered multiple sequence alignments.

## Table of Contents

- [Overview](#overview)
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