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arzwa committed Sep 12, 2022
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Whale.jl is a julia library for **joint inference of gene tree topologies and
their reconciliations to a species tree**. Whale uses the **amalgamation**
method of Szollosi et al. (2014) to efficiently compute the marginal likelihood
of the gene family under a duplication-loss model of gene family evolution over
a distribution of tree topologies. Whale also implements a duplication-loss and
whole-genome duplication (DLWGD) model (Rabier et al. 2014, Zwaenepoel et al.
2019). The latter can be used for the inference of ancient whole-genome
duplications (WGDs) from gene trees while taking into account gene tree and
reconciliation uncertainty.
method of [Szollosi et al. (2014)](https://doi.org/10.1093/sysbio/syt054)
to efficiently compute the marginal likelihood of the gene family under a
duplication-loss model of gene family evolution over a distribution of tree
topologies. Whale also implements a duplication-loss and whole-genome
duplication (DLWGD) model (Rabier et al. 2014, Zwaenepoel et al. 2019). The
latter can be used for the inference of ancient whole-genome duplications
(WGDs) from gene trees while taking into account gene tree and reconciliation
uncertainty.

More specifically, this library can be used to

- Statistically assess hypothetical whole-genome duplication (WGD) events in a
species phylogeny.
species phylogeny using maximum likelihood estimation (MLE) or Bayesian
inference.
- Infer lineage-specific gene duplication and loss rates for a species
phylogeny.
- Infer high-quality (reconciled) gene trees given a known species tree using
Bayesian gene tree reconciliation [cf. Szöllősi *et
al.*](https://academic.oup.com/sysbio/article/64/1/e42/1634124)
Bayesian gene tree reconciliation.
- Conduct Bayesian orthology inference.
- All of the above at once.

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