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Merge branch 'master' of https://github.com/VIB-PSB/ksrates
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lohausr committed Aug 23, 2021
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5 changes: 2 additions & 3 deletions README.md
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Expand Up @@ -16,7 +16,7 @@ To position ancient WGD events with respect to speciation events in a phylogeny,

*ksrates* is user-friendly command-line tool and [Nextflow](https://github.com/nextflow-io/nextflow) pipeline to compare paralog and ortholog *K*<sub>S</sub> distributions derived from genomic or transcriptomic sequences. *ksrates* estimates differences in synonymous substitution rates among the lineages involved and generates an adjusted mixed plot of paralog and ortholog *K*<sub>S</sub> distributions that allows to assess the relative phylogenetic positioning of presumed WGD and speciation events.

For more details, see our [preprint](https://www.biorxiv.org/content/10.1101/2021.02.28.433234v1) and the documentation below.
For more details, see the related [publication](https://doi.org/10.1093/bioinformatics/btab602) and the documentation below.

## Documentation

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If you publish results generated using *ksrates*, please cite:

Sensalari, C., Maere, S., and Lohaus, R. (2021) *ksrates*: positioning whole-genome duplications relative to speciation events using rate-adjusted mixed paralog&ndash;ortholog *K*<sub>S</sub> distributions. *bioRxiv* 2021.02.28.433234 [doi: 10.1101/2021.02.28.433234](https://doi.org/10.1101/2021.02.28.433234)
>This article is a preprint and has not been certified by peer review [[what does this mean?](https://www.biorxiv.org/content/what-unrefereed-preprint)].
Sensalari C., Maere S. and Lohaus R. (2021) *ksrates*: positioning whole-genome duplications relative to speciation events in *K*<sub>S</sub> distributions. *Bioinformatics*, btab602, [doi: https://doi.org/10.1093/bioinformatics/btab602](https://doi.org/10.1093/bioinformatics/btab602)

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## Acknowledgements
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Expand Up @@ -4,4 +4,4 @@ How to cite us

If you publish results generated using *ksrates*, please cite:

Sensalari C., Maere S. and Lohaus R. (2021) *ksrates*: positioning whole-genome duplications relative to speciation events using rate-adjusted mixed paralog--ortholog *K*:sub:`S` distributions. *bioRxiv* 2021.02.28.433234 `doi: https://doi.org/10.1101/2021.02.28.433234 <https://doi.org/10.1101/2021.02.28.433234>`__
Sensalari C., Maere S. and Lohaus R. (2021) *ksrates*: positioning whole-genome duplications relative to speciation events in *K*:sub:`S` distributions. *Bioinformatics*, btab602, `doi: https://doi.org/10.1093/bioinformatics/btab602 <https://doi.org/10.1093/bioinformatics/btab602>`__
2 changes: 1 addition & 1 deletion doc/source/concept.rst
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Expand Up @@ -9,7 +9,7 @@ However, when the lineages involved exhibit different substitution rates, the va

*ksrates* is an open-source tool offering a rate-adjustment strategy that brings all the distributions to a common *K*:sub:`S` scale by compensating for the differences in synonymous substitution rates relative to the species of interest, the focal species. The final mixed plot produced by *ksrates* features rate-adjusted positions of the ortholog *K*:sub:`S` estimates of species divergence times that help to clarify the phylogenetic placement of WGDs inferred in the focal species.

For more detail about the methodology, please see our `preprint <https://www.biorxiv.org/content/10.1101/2021.02.28.433234v1>`__.
For more detail about the methodology, please see the related `publication <https://doi.org/10.1093/bioinformatics/btab602>`__.


.. _`explained_example`:
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