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22 changes: 9 additions & 13 deletions README.md
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# ErmineR <img src="ermineR.png" align="right" height="100px"/>

[![Build
Status](https://travis-ci.org/PavlidisLab/ermineR.svg?branch=master)](https://travis-ci.org/PavlidisLab/ermineR)
[![codecov](https://codecov.io/gh/PavlidisLab/ermineR/branch/master/graph/badge.svg)](https://codecov.io/gh/PavlidisLab/ermineR)

This is an R wrapper for Pavlidis Lab’s
[ermineJ](http://erminej.msl.ubc.ca/). A tool for gene set enrichment
analysis with multifunctionality correction.
Expand Down Expand Up @@ -140,12 +136,12 @@ head(gsrOut$results) %>% knitr::kable()

| Name | ID | NumProbes | NumGenes | RawScore | Pval | CorrectedPvalue | MFPvalue | CorrectedMFPvalue | Multifunctionality | Same as | GeneMembers |
|:--------------------------------|:-------------|----------:|---------:|---------:|-------:|----------------:|---------:|------------------:|-------------------:|:--------|:----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| protein folding | <GO:0006457> | 40 | 24 | 3.198073 | 0.0000 | 0.0000000 | 0.000000 | 0.0000000 | 0.214 | NA | AIP\|CALR\|CCT5\|CCT6A\|CCT8L2\|CDC37L1\|CLGN\|CLPX\|DNAJB1\|DNAJB4\|GAK\|HSP90AA1\|HSPA1A\|HSPA9\|HSPB6\|HSPD1\|NUDC\|PFDN6\|PTGES3\|RUVBL2\|ST13\|TCP1\|TOR1A\|UGGT1\| |
| unfolded protein binding | <GO:0051082> | 52 | 29 | 3.299625 | 0.0000 | 0.0000000 | 0.000000 | 0.0000000 | 0.258 | NA | AIP\|CALR\|CCT5\|CCT6A\|CCT8L2\|CDC37L1\|CHAF1A\|CLGN\|CLPX\|DNAJB1\|DNAJB4\|HSP90AA1\|HSPA1A\|HSPA9\|HSPB6\|HSPD1\|HTRA2\|NUDC\|PFDN6\|PTGES3\|RUVBL2\|SHQ1\|SRSF10\|TAPBP\|TCP1\|TOMM20\|TOR1A\|TUBB4B\|UGGT1\| |
| cytosol | <GO:0005829> | 74 | 41 | 2.118055 | 0.0001 | 0.0031670 | 0.000600 | 0.0190000 | 0.483 | NA | AAMP\|AIP\|ARC\|BHMT2\|CALR\|CCT5\|CCT6A\|CDC37L1\|CLPX\|CRABP1\|DNAJB1\|DNAJB4\|EPHB2\|FRS2\|GAK\|GEMIN2\|HCK\|HSP90AA1\|HSPA1A\|HSPB6\|HSPD1\|HTRA2\|NELFA\|NUDC\|OGG1\|PASK\|PEX5\|PIKFYVE\|POLR3K\|PRKCI\|PTGES3\|RUVBL2\|SHQ1\|SPHK1\|SRSF10\|ST13\|TCP1\|TOR1A\|TUBB4B\|UNC13B\|USP33\| |
| cellular component assembly | <GO:0022607> | 45 | 22 | 2.386422 | 0.0027 | 0.0641250 | 0.006400 | 0.1520000 | 0.560 | NA | ARC\|CALR\|CHAF1A\|CLGN\|DDX46\|EPHB2\|GAK\|GEMIN2\|HSP90AA1\|HSPA1A\|HSPA9\|HSPD1\|PFDN6\|PIKFYVE\|PTGES3\|RUVBL2\|SHQ1\|SRSF10\|TAPBP\|TCP1\|UNC13B\|ZNF207\| |
| organelle organization | <GO:0006996> | 34 | 20 | 2.356244 | 0.0035 | 0.0665000 | 0.014600 | 0.1541111 | 0.956 | NA | ARC\|CALR\|GAK\|HSP90AA1\|HSPA1A\|HSPA9\|HSPD1\|HTRA2\|NUDC\|PEX5\|PIKFYVE\|PRKCI\|PTGES3\|RUVBL2\|TOMM20\|TOR1A\|TUBB4B\|UNC13B\|VPS8\|ZNF207\| |
| cellular component organization | <GO:0016043> | 68 | 35 | 2.120207 | 0.0041 | 0.0649167 | 0.009901 | 0.1343659 | 0.735 | NA | ARC\|CALR\|CHAF1A\|CLGN\|DDX46\|EPHB2\|FBLN2\|GAK\|GEMIN2\|HCK\|HSP90AA1\|HSPA1A\|HSPA9\|HSPD1\|HTRA2\|NUDC\|PEX5\|PFDN6\|PIKFYVE\|PRKCI\|PTGES3\|RUVBL2\|SEMA3B\|SHQ1\|SRSF10\|SULF1\|TAPBP\|TCP1\|TOMM20\|TOR1A\|TUBB4B\|UNC13B\|USP33\|VPS8\|ZNF207\| |
| protein folding | <GO:0006457> | 40 | 24 | 3.198073 | 0.0000 | 0.000000 | 0.0000 | 0.0000000 | 0.214 | NA | AIP\|CALR\|CCT5\|CCT6A\|CCT8L2\|CDC37L1\|CLGN\|CLPX\|DNAJB1\|DNAJB4\|GAK\|HSP90AA1\|HSPA1A\|HSPA9\|HSPB6\|HSPD1\|NUDC\|PFDN6\|PTGES3\|RUVBL2\|ST13\|TCP1\|TOR1A\|UGGT1\| |
| unfolded protein binding | <GO:0051082> | 52 | 29 | 3.299625 | 0.0000 | 0.000000 | 0.0000 | 0.0000000 | 0.258 | NA | AIP\|CALR\|CCT5\|CCT6A\|CCT8L2\|CDC37L1\|CHAF1A\|CLGN\|CLPX\|DNAJB1\|DNAJB4\|HSP90AA1\|HSPA1A\|HSPA9\|HSPB6\|HSPD1\|HTRA2\|NUDC\|PFDN6\|PTGES3\|RUVBL2\|SHQ1\|SRSF10\|TAPBP\|TCP1\|TOMM20\|TOR1A\|TUBB4B\|UGGT1\| |
| cytosol | <GO:0005829> | 74 | 41 | 2.118055 | 0.0002 | 0.006333 | 0.0002 | 0.0063330 | 0.483 | NA | AAMP\|AIP\|ARC\|BHMT2\|CALR\|CCT5\|CCT6A\|CDC37L1\|CLPX\|CRABP1\|DNAJB1\|DNAJB4\|EPHB2\|FRS2\|GAK\|GEMIN2\|HCK\|HSP90AA1\|HSPA1A\|HSPB6\|HSPD1\|HTRA2\|NELFA\|NUDC\|OGG1\|PASK\|PEX5\|PIKFYVE\|POLR3K\|PRKCI\|PTGES3\|RUVBL2\|SHQ1\|SPHK1\|SRSF10\|ST13\|TCP1\|TOR1A\|TUBB4B\|UNC13B\|USP33\| |
| cellular component assembly | <GO:0022607> | 45 | 22 | 2.386422 | 0.0025 | 0.059375 | 0.0072 | 0.1140000 | 0.560 | NA | ARC\|CALR\|CHAF1A\|CLGN\|DDX46\|EPHB2\|GAK\|GEMIN2\|HSP90AA1\|HSPA1A\|HSPA9\|HSPD1\|PFDN6\|PIKFYVE\|PTGES3\|RUVBL2\|SHQ1\|SRSF10\|TAPBP\|TCP1\|UNC13B\|ZNF207\| |
| organelle organization | <GO:0006996> | 34 | 20 | 2.356244 | 0.0032 | 0.060800 | 0.0155 | 0.1636111 | 0.956 | NA | ARC\|CALR\|GAK\|HSP90AA1\|HSPA1A\|HSPA9\|HSPD1\|HTRA2\|NUDC\|PEX5\|PIKFYVE\|PRKCI\|PTGES3\|RUVBL2\|TOMM20\|TOR1A\|TUBB4B\|UNC13B\|VPS8\|ZNF207\| |
| cellular component organization | <GO:0016043> | 68 | 35 | 2.120207 | 0.0036 | 0.057000 | 0.0070 | 0.1662500 | 0.735 | NA | ARC\|CALR\|CHAF1A\|CLGN\|DDX46\|EPHB2\|FBLN2\|GAK\|GEMIN2\|HCK\|HSP90AA1\|HSPA1A\|HSPA9\|HSPD1\|HTRA2\|NUDC\|PEX5\|PFDN6\|PIKFYVE\|PRKCI\|PTGES3\|RUVBL2\|SEMA3B\|SHQ1\|SRSF10\|SULF1\|TAPBP\|TCP1\|TOMM20\|TOR1A\|TUBB4B\|UNC13B\|USP33\|VPS8\|ZNF207\| |

#### Use Precision Recall with gene scores

Expand All @@ -171,9 +167,9 @@ head(precRecallOut$results) %>% knitr::kable()
| binding | <GO:0005488> | 143 | 81 | 0.9992282 | 0.0000 | 0.0000000 | 0.0000 | 0.0000000 | 0.486 | NA | AAMP\|AIP\|ARC\|ARF3\|BHMT2\|C5AR2\|CACNA1F\|CALR\|CCNG1\|CCT5\|CCT6A\|CCT8L2\|CDC37L1\|CHAF1A\|CLGN\|CLPX\|CPT1A\|CRABP1\|DDX46\|DMBT1\|DNAJB1\|DNAJB4\|DZIP3\|EPHB2\|FBLN2\|FOXB1\|FPR3\|FRS2\|GAK\|GEMIN2\|GPR17\|HCK\|HMGCR\|HSP90AA1\|HSPA1A\|HSPA9\|HSPB6\|HSPD1\|HTRA2\|ITIH2\|KCNJ1\|LIPF\|MAN1B1\|NELFA\|NR2E3\|NUDC\|OGG1\|PASK\|PEX5\|PFDN6\|PIKFYVE\|PLCH1\|POLR3K\|PPARA\|PRKCI\|PRPSAP1\|PTGES3\|RUVBL2\|SEMA3B\|SHOX2\|SHQ1\|SLC22A14\|SLC24A1\|SPHK1\|SRSF10\|ST13\|SULF1\|TAPBP\|TBKBP1\|TCP1\|TNFRSF12A\|TOMM20\|TOR1A\|TUBB4B\|UGGT1\|UNC13B\|USP33\|VPS8\|YIPF2\|ZCCHC8\|ZNF207\| |
| protein folding | <GO:0006457> | 40 | 24 | 0.7176581 | 0.0000 | 0.0000000 | 0.0000 | 0.0000000 | 0.214 | NA | AIP\|CALR\|CCT5\|CCT6A\|CCT8L2\|CDC37L1\|CLGN\|CLPX\|DNAJB1\|DNAJB4\|GAK\|HSP90AA1\|HSPA1A\|HSPA9\|HSPB6\|HSPD1\|NUDC\|PFDN6\|PTGES3\|RUVBL2\|ST13\|TCP1\|TOR1A\|UGGT1\| |
| unfolded protein binding | <GO:0051082> | 52 | 29 | 0.8507590 | 0.0000 | 0.0000000 | 0.0000 | 0.0000000 | 0.258 | NA | AIP\|CALR\|CCT5\|CCT6A\|CCT8L2\|CDC37L1\|CHAF1A\|CLGN\|CLPX\|DNAJB1\|DNAJB4\|HSP90AA1\|HSPA1A\|HSPA9\|HSPB6\|HSPD1\|HTRA2\|NUDC\|PFDN6\|PTGES3\|RUVBL2\|SHQ1\|SRSF10\|TAPBP\|TCP1\|TOMM20\|TOR1A\|TUBB4B\|UGGT1\| |
| protein binding | <GO:0005515> | 127 | 73 | 0.9569410 | 0.0001 | 0.0023750 | 0.0002 | 0.0047500 | 0.369 | NA | AAMP\|AIP\|ARC\|ARF3\|C5AR2\|CALR\|CCNG1\|CCT5\|CCT6A\|CCT8L2\|CDC37L1\|CHAF1A\|CLGN\|CLPX\|CPT1A\|CRABP1\|DDX46\|DMBT1\|DNAJB1\|DNAJB4\|DZIP3\|EPHB2\|FBLN2\|FOXB1\|FPR3\|FRS2\|GAK\|GEMIN2\|GPR17\|HCK\|HMGCR\|HSP90AA1\|HSPA1A\|HSPA9\|HSPB6\|HSPD1\|HTRA2\|ITIH2\|NELFA\|NR2E3\|NUDC\|OGG1\|PASK\|PEX5\|PFDN6\|PIKFYVE\|POLR3K\|PPARA\|PRKCI\|PRPSAP1\|PTGES3\|RUVBL2\|SEMA3B\|SHQ1\|SLC22A14\|SLC24A1\|SPHK1\|SRSF10\|ST13\|TAPBP\|TBKBP1\|TCP1\|TNFRSF12A\|TOMM20\|TOR1A\|TUBB4B\|UGGT1\|UNC13B\|USP33\|VPS8\|YIPF2\|ZCCHC8\|ZNF207\| |
| cytosol | <GO:0005829> | 74 | 41 | 0.7108333 | 0.0012 | 0.0228000 | 0.0017 | 0.0323000 | 0.483 | NA | AAMP\|AIP\|ARC\|BHMT2\|CALR\|CCT5\|CCT6A\|CDC37L1\|CLPX\|CRABP1\|DNAJB1\|DNAJB4\|EPHB2\|FRS2\|GAK\|GEMIN2\|HCK\|HSP90AA1\|HSPA1A\|HSPB6\|HSPD1\|HTRA2\|NELFA\|NUDC\|OGG1\|PASK\|PEX5\|PIKFYVE\|POLR3K\|PRKCI\|PTGES3\|RUVBL2\|SHQ1\|SPHK1\|SRSF10\|ST13\|TCP1\|TOR1A\|TUBB4B\|UNC13B\|USP33\| |
| cellular anatomical entity | <GO:0110165> | 142 | 80 | 0.9860952 | 0.0022 | 0.0348333 | 0.0022 | 0.0348333 | 0.442 | NA | AAMP\|AIP\|ARC\|ARF3\|BHMT2\|C5AR2\|CACNA1F\|CALR\|CCNG1\|CCT5\|CCT6A\|CDC37L1\|CHAF1A\|CLGN\|CLPX\|CPT1A\|CRABP1\|DDX46\|DMBT1\|DNAJB1\|DNAJB4\|DZIP3\|EPHB2\|FBLN2\|FOXB1\|FPR3\|FRS2\|GAK\|GEMIN2\|GPR17\|HCK\|HMGCR\|HSP90AA1\|HSPA1A\|HSPA9\|HSPB6\|HSPD1\|HTRA2\|ITIH2\|KCNJ1\|LIPF\|MAN1B1\|NELFA\|NR2E3\|NUDC\|OGG1\|PASK\|PEX5\|PFDN6\|PIKFYVE\|PLCH1\|POLR3K\|PPARA\|PRKCI\|PRPSAP1\|PTGES3\|RUVBL2\|SEMA3B\|SHOX2\|SHQ1\|SLC22A14\|SLC24A1\|SPHK1\|SRSF10\|ST13\|SULF1\|TAPBP\|TBKBP1\|TCP1\|TNFRSF12A\|TOMM20\|TOR1A\|TUBB4B\|UGGT1\|UNC13B\|USP33\|VPS8\|YIPF2\|ZCCHC8\|ZNF207\| |
| cytosol | <GO:0005829> | 74 | 41 | 0.7108333 | 0.0003 | 0.0071250 | 0.0005 | 0.0118750 | 0.483 | NA | AAMP\|AIP\|ARC\|BHMT2\|CALR\|CCT5\|CCT6A\|CDC37L1\|CLPX\|CRABP1\|DNAJB1\|DNAJB4\|EPHB2\|FRS2\|GAK\|GEMIN2\|HCK\|HSP90AA1\|HSPA1A\|HSPB6\|HSPD1\|HTRA2\|NELFA\|NUDC\|OGG1\|PASK\|PEX5\|PIKFYVE\|POLR3K\|PRKCI\|PTGES3\|RUVBL2\|SHQ1\|SPHK1\|SRSF10\|ST13\|TCP1\|TOR1A\|TUBB4B\|UNC13B\|USP33\| |
| protein binding | <GO:0005515> | 127 | 73 | 0.9569410 | 0.0005 | 0.0095000 | 0.0006 | 0.0114000 | 0.369 | NA | AAMP\|AIP\|ARC\|ARF3\|C5AR2\|CALR\|CCNG1\|CCT5\|CCT6A\|CCT8L2\|CDC37L1\|CHAF1A\|CLGN\|CLPX\|CPT1A\|CRABP1\|DDX46\|DMBT1\|DNAJB1\|DNAJB4\|DZIP3\|EPHB2\|FBLN2\|FOXB1\|FPR3\|FRS2\|GAK\|GEMIN2\|GPR17\|HCK\|HMGCR\|HSP90AA1\|HSPA1A\|HSPA9\|HSPB6\|HSPD1\|HTRA2\|ITIH2\|NELFA\|NR2E3\|NUDC\|OGG1\|PASK\|PEX5\|PFDN6\|PIKFYVE\|POLR3K\|PPARA\|PRKCI\|PRPSAP1\|PTGES3\|RUVBL2\|SEMA3B\|SHQ1\|SLC22A14\|SLC24A1\|SPHK1\|SRSF10\|ST13\|TAPBP\|TBKBP1\|TCP1\|TNFRSF12A\|TOMM20\|TOR1A\|TUBB4B\|UGGT1\|UNC13B\|USP33\|VPS8\|YIPF2\|ZCCHC8\|ZNF207\| |
| cellular anatomical entity | <GO:0110165> | 142 | 80 | 0.9860952 | 0.0011 | 0.0174167 | 0.0014 | 0.0221667 | 0.442 | NA | AAMP\|AIP\|ARC\|ARF3\|BHMT2\|C5AR2\|CACNA1F\|CALR\|CCNG1\|CCT5\|CCT6A\|CDC37L1\|CHAF1A\|CLGN\|CLPX\|CPT1A\|CRABP1\|DDX46\|DMBT1\|DNAJB1\|DNAJB4\|DZIP3\|EPHB2\|FBLN2\|FOXB1\|FPR3\|FRS2\|GAK\|GEMIN2\|GPR17\|HCK\|HMGCR\|HSP90AA1\|HSPA1A\|HSPA9\|HSPB6\|HSPD1\|HTRA2\|ITIH2\|KCNJ1\|LIPF\|MAN1B1\|NELFA\|NR2E3\|NUDC\|OGG1\|PASK\|PEX5\|PFDN6\|PIKFYVE\|PLCH1\|POLR3K\|PPARA\|PRKCI\|PRPSAP1\|PTGES3\|RUVBL2\|SEMA3B\|SHOX2\|SHQ1\|SLC22A14\|SLC24A1\|SPHK1\|SRSF10\|ST13\|SULF1\|TAPBP\|TBKBP1\|TCP1\|TNFRSF12A\|TOMM20\|TOR1A\|TUBB4B\|UGGT1\|UNC13B\|USP33\|VPS8\|YIPF2\|ZCCHC8\|ZNF207\| |

#### Use ORA with a hitlist

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1 change: 0 additions & 1 deletion README.rmd
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Expand Up @@ -8,7 +8,6 @@ devtools::load_all()

# ErmineR <img src="ermineR.png" align="right" height="100px"/>

[![Build Status](https://travis-ci.org/PavlidisLab/ermineR.svg?branch=master)](https://travis-ci.org/PavlidisLab/ermineR) [![codecov](https://codecov.io/gh/PavlidisLab/ermineR/branch/master/graph/badge.svg)](https://codecov.io/gh/PavlidisLab/ermineR)

This is an R wrapper for Pavlidis Lab's [ermineJ](http://erminej.msl.ubc.ca/). A tool for gene set enrichment analysis with multifunctionality correction.

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45 changes: 0 additions & 45 deletions appveyor.yml

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