[NTR]Limbal epithelial stem cell of the cornea

[emquardokus]

Please check that the term does not already exist by using the ontology search tool OLS:
https://www.ebi.ac.uk/ols4/ontologies/cl

Preferred term label
Limbal epithelial stem cell of the cornea

Synonyms (add reference(s), please)
LSC (limbal stem cell)

Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX)
1)Figure 3 gives location with respect to other cell types and structures from Secker GA, Daniels JT. Limbal epithelial stem cells of the cornea. 2009 Jun 30. In: StemBook [Internet]. Cambridge (MA): Harvard Stem Cell Institute; 2008-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK27054/ doi: 10.3824/stembook.1.48.1

Human limbus: "Limbal epithelial stem cells reside in the basal layer of the epithelium (Ep), which undulates at the limbus. Daughter transient amplifying cells (TACs) divide and migrate towards the central cornea (arrowed) to replenish the epithelium, which rests on Bowman's layer (BL). The stroma (St) of the limbal epithelial stem cell niche is populated with fibroblasts and melanocytes and also has a blood supply." "At the corneo-scleral junction in an area known as the limbus, there is a population of limbal epithelial stem cells (LESCs). LESCs share common features with other adult somatic stem cells including small size (Romano et al., 2003) and high nuclear to cytoplasmic ratio (Barrandon and Green, 1987). They also lack expression of differentiation markers such as cytokeratins 3 and 12 (Kurpakus et al., 1990; Schermer et al., 1986)."
"Limbal stem cells (LSC) represent a quiescent cell population with proliferative capacity residing in the basal epithelial
layer of the limbus within a cellular niche. "

2. https://eyewiki.org/Limbal_Stem_Cell_Deficiency
3. Gonzalez G, Sasamoto Y, Ksander BR, Frank MH, Frank NY. Limbal stem cells: identity, developmental origin, and therapeutic potential. Wiley Interdiscip Rev Dev Biol. 2018 Mar;7(2):10.1002/wdev.303. doi: 10.1002/wdev.303. Epub 2017 Nov 3. PMID: 29105366; PMCID: PMC5814333.

Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols4/ontologies/cl)

corneal epithelial cell CL:0000575--> Limbal epithelial stem cell of the cornea (is a) type of corneal epithelial cell

Anatomical structure where the cell type is found (check Uberon for anatomical structures: https://www.ebi.ac.uk/ols4/ontologies/uberon)

corneo-scleral junction UBERON:0006761 --> has some basal lamina of epithelium UBERON:0000482 has some--> epithelial fate stem cell CL:0000036--> Limbal epithelial stem cell of the cornea (is a) type of epithelial fate stem cell

corneal epithelium UBERON:0001772

Your ORCID
0000-0001-7655-4833

Additional notes or concerns