diff --git a/.changeset/funny-toes-shave.md b/.changeset/funny-toes-shave.md
new file mode 100644
index 00000000..85033b0f
--- /dev/null
+++ b/.changeset/funny-toes-shave.md
@@ -0,0 +1,5 @@
+---
+'@myst-theme/styles': patch
+---
+
+Add support for styling sphinx
diff --git a/styles/app.css b/styles/app.css
index 0e47bfe4..b752a005 100644
--- a/styles/app.css
+++ b/styles/app.css
@@ -10,6 +10,7 @@
 @import './block-styles.css';
 @import './jupyter.css';
 @import './tasklists.css';
+@import './sphinx.css';
 @import './grid.css';
 @import './hover.css';
 @import './proof.css';
diff --git a/styles/index.js b/styles/index.js
index f728a0fd..97479215 100644
--- a/styles/index.js
+++ b/styles/index.js
@@ -210,6 +210,26 @@ const safeList = [
   'framed',
   'shaded-children',
   'rounded-children',
+  'sphinx-desc-addname',
+  'sphinx-desc-inline',
+  'sphinx-desc-name',
+  'sphinx-desc-optional',
+  'sphinx-desc-parameterlist',
+  'sphinx-desc-returns',
+  'sphinx-desc-sig-element',
+  'sphinx-desc-sig-keyword',
+  'sphinx-desc-sig-keyword-type',
+  'sphinx-desc-sig-literal-char',
+  'sphinx-desc-sig-literal-number',
+  'sphinx-desc-sig-literal-string',
+  'sphinx-desc-sig-name',
+  'sphinx-desc-signature',
+  'sphinx-desc-signature-line',
+  'sphinx-desc-sig-operator',
+  'sphinx-desc-sig-punctuation',
+  'sphinx-desc-sig-space',
+  'sphinx-desc-type',
+  'sphinx-desc-type-parameter',
 ];
 
 module.exports = {
diff --git a/styles/sphinx.css b/styles/sphinx.css
new file mode 100644
index 00000000..00dc686d
--- /dev/null
+++ b/styles/sphinx.css
@@ -0,0 +1,56 @@
+.sphinx-desc-addname,
+.sphinx-desc-inline,
+.sphinx-desc-name,
+.sphinx-desc-returns,
+.sphinx-desc-optional,
+.sphinx-desc-parameterlist,
+.sphinx-desc-sig-element,
+.sphinx-desc-sig-keyword,
+.sphinx-desc-sig-keyword-type,
+.sphinx-desc-sig-literal-char,
+.sphinx-desc-sig-literal-number,
+.sphinx-desc-sig-literal-string,
+.sphinx-desc-sig-name,
+.sphinx-desc-signature-line,
+.sphinx-desc-sig-operator,
+.sphinx-desc-sig-punctuation,
+.sphinx-desc-sig-space,
+.sphinx-desc-type,
+.sphinx-desc-type-parameter {
+  @apply whitespace-pre;
+}
+.sphinx-desc-name {
+  @apply font-bold text-[1.1em];
+}
+.sphinx-desc-signature {
+  @apply font-mono font-light;
+}
+.sphinx-desc-returns {
+  @apply before:content-['_→_'];
+}
+
+/* .sphinx-desc > .sphinx-desc-signature */
+dl > dt:has([class^='sphinx-desc-']) {
+  @apply font-mono font-light;
+}
+
+/* .sphinx-desc > .sphinx-desc-signature */
+dl > dt:has([class^='sphinx-desc-']) > em {
+  @apply whitespace-pre;
+}
+
+/* .sphinx-desc > .sphinx-desc-content > dl:not(:has(.sphinx-dex)) */
+dl:has(> dt > [class^='sphinx-desc-']) > dd > dl:not(:has(> dt > [class^='sphinx-desc-'])) {
+  display: grid;
+  grid-template-columns: fit-content(30%) auto;
+}
+
+/* .sphinx-desc > .sphinx-desc-content > dl:not(:has(.sphinx-dex)) > dd > p */
+dl:has(> dt > [class^='sphinx-desc-']) > dd > dl:not(:has(> dt > [class^='sphinx-desc-'])) > dd > p {
+  margin: unset !important; /* Undo some generic theming */
+}
+
+/* .sphinx-desc > .sphinx-desc-content > dl:not(:has(.sphinx-dex)) > *:is(dt, dd) */
+dl:has(> dt > [class^='sphinx-desc-']) > dd > dl:not(:has(> dt > [class^='sphinx-desc-'])) > *:is(dt, dd) {
+  margin: unset !important; /* Undo some generic theming */
+}