diff --git a/.rubocop.yml b/.rubocop.yml
index 47e95a35f..44a322aef 100644
--- a/.rubocop.yml
+++ b/.rubocop.yml
@@ -26,3 +26,9 @@ RSpec/Focus:
 
 RSpec/MultipleExpectations:
   Enabled: false
+
+Style/TrailingCommaInArrayLiteral:
+  EnforcedStyleForMultiline: consistent_comma
+
+Style/TrailingCommaInHashLiteral:
+  EnforcedStyleForMultiline: consistent_comma
diff --git a/CHANGELOG.md b/CHANGELOG.md
index 0ff40bbcc..a4908ec2a 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -2,6 +2,7 @@
 
 ## [Unreleased]
 
+- Excluded `LD_LIBRARY_PATH` and `PYTHONHOME` app config vars when invoking subprocesses during the build. ([#1565](https://github.com/heroku/heroku-buildpack-python/pull/1565))
 
 ## [v248] - 2024-04-09
 
diff --git a/spec/hatchet/django_spec.rb b/spec/hatchet/django_spec.rb
index c128c0673..865d5b833 100644
--- a/spec/hatchet/django_spec.rb
+++ b/spec/hatchet/django_spec.rb
@@ -2,10 +2,23 @@
 
 require_relative '../spec_helper'
 
+# Tests that broken user-provided env vars don't take precedence over those set by this buildpack
+# and break running Python. This is particularly important when using shared builds of Python,
+# since they rely upon `LD_LIBRARY_PATH` being correct. This list of env vars is based on those
+# that used to be set to different values by `bin/release` in very old versions of the buildpack:
+# https://github.com/heroku/heroku-buildpack-python/blob/27abdfe7d7ad104dabceb45641415251e965671c/bin/release#L11-L18
+BROKEN_CONFIG_VARS = {
+  LD_LIBRARY_PATH: '/invalid-path',
+  LIBRARY_PATH: '/invalid-path',
+  PATH: '/invalid-path',
+  PYTHONHOME: '/invalid-path',
+  PYTHONPATH: '/invalid-path',
+}.freeze
+
 RSpec.describe 'Django support' do
   describe 'collectstatic' do
     context 'when building a Django project' do
-      let(:app) { Hatchet::Runner.new('python-getting-started') }
+      let(:app) { Hatchet::Runner.new('python-getting-started', config: BROKEN_CONFIG_VARS) }
 
       it 'runs collectstatic' do
         app.deploy do |app|
diff --git a/spec/hatchet/profile_d_scripts_spec.rb b/spec/hatchet/profile_d_scripts_spec.rb
index 38889a849..434d6ccad 100644
--- a/spec/hatchet/profile_d_scripts_spec.rb
+++ b/spec/hatchet/profile_d_scripts_spec.rb
@@ -46,7 +46,7 @@
         'PYTHONHOME=/this-should-be-overridden',
         'PYTHONPATH=/this-should-be-preserved',
         'PYTHONUNBUFFERED=this-should-be-overridden',
-        'WEB_CONCURRENCY=this-should-be-preserved'
+        'WEB_CONCURRENCY=this-should-be-preserved',
       ]
       app.run_multi(list_envs_cmd, heroku: { env: user_env_vars.join(';'), type: 'example-worker' }) do |output, _|
         expect(output).to eq(<<~OUTPUT)
diff --git a/vendor/buildpack-stdlib_v8.sh b/vendor/buildpack-stdlib_v8.sh
index afb6580ed..ca7db3a97 100755
--- a/vendor/buildpack-stdlib_v8.sh
+++ b/vendor/buildpack-stdlib_v8.sh
@@ -95,7 +95,7 @@ _env_blacklist() {
   if [ -n "$regex" ]; then
     regex="|$regex"
   fi
-  echo "^(PATH|GIT_DIR|CPATH|CPPATH|LD_PRELOAD|LIBRARY_PATH$regex)$"
+  echo "^(PATH|CPATH|CPPATH|LD_PRELOAD|LIBRARY_PATH|LD_LIBRARY_PATH|PYTHONHOME$regex)$"
 }
 
 # Usage: $ export-env ENV_DIR WHITELIST BLACKLIST