diff --git a/vllm/model_executor/layers/fused_moe/configs/E=8,N=14336,device_name=AMD_Instinct_MI300X.json b/vllm/model_executor/layers/fused_moe/configs/E=8,N=14336,device_name=AMD_Instinct_MI300X.json
new file mode 100644
index 0000000000000..93472eb08a462
--- /dev/null
+++ b/vllm/model_executor/layers/fused_moe/configs/E=8,N=14336,device_name=AMD_Instinct_MI300X.json
@@ -0,0 +1,128 @@
+{
+    "1": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_stages": 0
+    },
+    "2": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_stages": 0
+    },
+    "4": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 64,
+        "num_stages": 1
+    },
+    "8": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 32,
+        "num_stages": 1
+    },
+    "16": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 8,
+        "num_stages": 1
+    },
+    "24": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 64,
+        "num_stages": 1
+    },
+    "32": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 8,
+        "num_stages": 1
+    },
+    "48": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 8,
+        "num_stages": 0
+    },
+    "64": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 8,
+        "num_stages": 0
+    },
+    "96": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 16,
+        "num_stages": 0
+    },
+    "128": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 8,
+        "num_stages": 0
+    },
+    "256": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 8,
+        "num_stages": 0
+    },
+    "512": {
+        "BLOCK_SIZE_M": 256,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 8,
+        "num_stages": 0
+    },
+    "1024": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_stages": 0
+    },
+    "1536": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_stages": 0
+    },
+    "2048": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 256,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_stages": 0
+    },
+    "3072": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 256,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_stages": 0
+    },
+    "4096": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_stages": 0
+    }
+}
diff --git a/vllm/model_executor/layers/fused_moe/configs/E=8,N=1792,device_name=AMD_Instinct_MI300X.json b/vllm/model_executor/layers/fused_moe/configs/E=8,N=1792,device_name=AMD_Instinct_MI300X.json
new file mode 100644
index 0000000000000..5bd9d71e8f9bb
--- /dev/null
+++ b/vllm/model_executor/layers/fused_moe/configs/E=8,N=1792,device_name=AMD_Instinct_MI300X.json
@@ -0,0 +1,110 @@
+{
+    "1": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 64
+    },
+    "2": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 32,
+        "GROUP_SIZE_M": 32
+    },
+    "4": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 8
+    },
+    "8": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1
+    },
+    "16": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1
+    },
+    "24": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1
+    },
+    "32": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 8
+    },
+    "48": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 8
+    },
+    "64": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1
+    },
+    "96": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 8
+    },
+    "128": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 32
+    },
+    "256": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1
+    },
+    "512": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1
+    },
+    "1024": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1
+    },
+    "1536": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1
+    },
+    "2048": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1
+    },
+    "3072": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1
+    },
+    "4096": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1
+    }
+}
diff --git a/vllm/model_executor/layers/fused_moe/configs/E=8,N=3584,device_name=AMD_Instinct_MI300X.json b/vllm/model_executor/layers/fused_moe/configs/E=8,N=3584,device_name=AMD_Instinct_MI300X.json
new file mode 100644
index 0000000000000..02e66280c1a3a
--- /dev/null
+++ b/vllm/model_executor/layers/fused_moe/configs/E=8,N=3584,device_name=AMD_Instinct_MI300X.json
@@ -0,0 +1,128 @@
+{
+    "1": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 8,
+        "num_stages": 0
+    },
+    "2": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_stages": 0
+    },
+    "4": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 32,
+        "GROUP_SIZE_M": 32,
+        "num_stages": 1
+    },
+    "8": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 8,
+        "num_stages": 1
+    },
+    "16": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 16,
+        "num_stages": 1
+    },
+    "24": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 8,
+        "num_stages": 1
+    },
+    "32": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 256,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 16,
+        "num_stages": 0
+    },
+    "48": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 16,
+        "num_stages": 1
+    },
+    "64": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 32,
+        "num_stages": 0
+    },
+    "96": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 16,
+        "num_stages": 0
+    },
+    "128": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 256,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 8,
+        "num_stages": 0
+    },
+    "256": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 8,
+        "num_stages": 0
+    },
+    "512": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_stages": 0
+    },
+    "1024": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_stages": 0
+    },
+    "1536": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_stages": 0
+    },
+    "2048": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_stages": 0
+    },
+    "3072": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_stages": 0
+    },
+    "4096": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_stages": 0
+    }
+}
diff --git a/vllm/model_executor/layers/fused_moe/configs/E=8,N=7168,device_name=AMD_Instinct_MI300X.json b/vllm/model_executor/layers/fused_moe/configs/E=8,N=7168,device_name=AMD_Instinct_MI300X.json
new file mode 100644
index 0000000000000..34c3b593d9799
--- /dev/null
+++ b/vllm/model_executor/layers/fused_moe/configs/E=8,N=7168,device_name=AMD_Instinct_MI300X.json
@@ -0,0 +1,128 @@
+{
+    "1": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_stages": 0
+    },
+    "2": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_stages": 1
+    },
+    "4": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 32,
+        "num_stages": 1
+    },
+    "8": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 8,
+        "num_stages": 1
+    },
+    "16": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 8,
+        "num_stages": 1
+    },
+    "24": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 8,
+        "num_stages": 1
+    },
+    "32": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 16,
+        "num_stages": 0
+    },
+    "48": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 16,
+        "num_stages": 0
+    },
+    "64": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 8,
+        "num_stages": 1
+    },
+    "96": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 8,
+        "num_stages": 0
+    },
+    "128": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 8,
+        "num_stages": 0
+    },
+    "256": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 8,
+        "num_stages": 0
+    },
+    "512": {
+        "BLOCK_SIZE_M": 256,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 8,
+        "num_stages": 0
+    },
+    "1024": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_stages": 0
+    },
+    "1536": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_stages": 0
+    },
+    "2048": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_stages": 0
+    },
+    "3072": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_stages": 0
+    },
+    "4096": {
+        "BLOCK_SIZE_M": 256,
+        "BLOCK_SIZE_N": 256,
+        "BLOCK_SIZE_K": 32,
+        "GROUP_SIZE_M": 1,
+        "num_stages": 0
+    }
+}