diff --git a/pkgs/applications/networking/pjsip/default.nix b/pkgs/applications/networking/pjsip/default.nix
index fe0e032dd2247..b267dee36909e 100644
--- a/pkgs/applications/networking/pjsip/default.nix
+++ b/pkgs/applications/networking/pjsip/default.nix
@@ -1,17 +1,18 @@
-{ lib
-, testers
-, stdenv
-, fetchFromGitHub
-, openssl
-, libsamplerate
-, swig
-, alsa-lib
-, AppKit
-, CoreFoundation
-, Security
-, python3
-, pythonSupport ? true
-, runCommand
+{
+  lib,
+  testers,
+  stdenv,
+  fetchFromGitHub,
+  openssl,
+  libsamplerate,
+  swig,
+  alsa-lib,
+  AppKit,
+  CoreFoundation,
+  Security,
+  python3,
+  pythonSupport ? true,
+  runCommand,
 }:
 stdenv.mkDerivation (finalAttrs: {
   pname = "pjsip";
@@ -24,22 +25,41 @@ stdenv.mkDerivation (finalAttrs: {
     hash = "sha256-LDA3o1QMrAxcGuOi/YRoMzXmw/wFkfDs2wweZuIJ2RY=";
   };
 
-  patches = [
-    ./fix-aarch64.patch
-  ];
+  patches = [ ./fix-aarch64.patch ];
+
+  postPatch = ''
+    substituteInPlace \
+      pjsip-apps/src/py_pjsua/setup.py \
+      pjsip-apps/src/swig/python/setup.py \
+      pjsip-apps/src/python/setup.py \
+      pjsip-apps/src/python/setup-vc.py \
+      --replace-fail "distutils.core" "setuptools"
+  '';
 
-  nativeBuildInputs =
-    lib.optionals pythonSupport [ swig python3 ];
+  nativeBuildInputs = lib.optionals pythonSupport [
+    swig
+    python3
+    python3.pkgs.build
+    python3.pkgs.installer
+    python3.pkgs.setuptools
+    python3.pkgs.wheel
+  ];
 
-  buildInputs = [ openssl libsamplerate ]
+  buildInputs =
+    [
+      openssl
+      libsamplerate
+    ]
     ++ lib.optional stdenv.isLinux alsa-lib
-    ++ lib.optionals stdenv.isDarwin [ AppKit CoreFoundation Security ];
+    ++ lib.optionals stdenv.isDarwin [
+      AppKit
+      CoreFoundation
+      Security
+    ];
 
-  env = lib.optionalAttrs stdenv.cc.isClang {
-    CXXFLAGS = "-std=c++11";
-  } // lib.optionalAttrs stdenv.isDarwin {
-    NIX_CFLAGS_LINK = "-headerpad_max_install_names";
-  };
+  env =
+    lib.optionalAttrs stdenv.cc.isClang { CXXFLAGS = "-std=c++11"; }
+    // lib.optionalAttrs stdenv.isDarwin { NIX_CFLAGS_LINK = "-headerpad_max_install_names"; };
 
   preConfigure = ''
     export LD=$CC
@@ -51,52 +71,55 @@ stdenv.mkDerivation (finalAttrs: {
 
   configureFlags = [ "--enable-shared" ];
 
-  outputs = [ "out" ]
-    ++ lib.optional pythonSupport "py";
-
-  postInstall = ''
-    mkdir -p $out/bin
-    cp pjsip-apps/bin/pjsua-* $out/bin/pjsua
-    mkdir -p $out/share/${finalAttrs.pname}-${finalAttrs.version}/samples
-    cp pjsip-apps/bin/samples/*/* $out/share/${finalAttrs.pname}-${finalAttrs.version}/samples
-  '' + lib.optionalString pythonSupport ''
-    (cd pjsip-apps/src/swig/python && \
-      python setup.py install --prefix=$py
-    )
-  '' + lib.optionalString stdenv.isDarwin ''
-    # On MacOS relative paths are used to refer to libraries. All libraries use
-    # a relative path like ../lib/*.dylib or ../../lib/*.dylib. We need to
-    # rewrite these to use absolute ones.
-
-    # First, find all libraries (and their symlinks) in our outputs to define
-    # the install_name_tool -change arguments we should pass.
-    readarray -t libraries < <(
-      for outputName in $(getAllOutputNames); do
-        find "''${!outputName}" \( -name '*.dylib*' -o -name '*.so*' \)
+  outputs = [ "out" ] ++ lib.optional pythonSupport "py";
+
+  postInstall =
+    ''
+      mkdir -p $out/bin
+      cp pjsip-apps/bin/pjsua-* $out/bin/pjsua
+      mkdir -p $out/share/${finalAttrs.pname}-${finalAttrs.version}/samples
+      cp pjsip-apps/bin/samples/*/* $out/share/${finalAttrs.pname}-${finalAttrs.version}/samples
+    ''
+    + lib.optionalString pythonSupport ''
+      (cd pjsip-apps/src/swig/python && \
+          python -m build --no-isolation --outdir dist/ --wheel
+          python -m installer --prefix $py dist/*.whl
+      )
+    ''
+    + lib.optionalString stdenv.isDarwin ''
+      # On MacOS relative paths are used to refer to libraries. All libraries use
+      # a relative path like ../lib/*.dylib or ../../lib/*.dylib. We need to
+      # rewrite these to use absolute ones.
+
+      # First, find all libraries (and their symlinks) in our outputs to define
+      # the install_name_tool -change arguments we should pass.
+      readarray -t libraries < <(
+        for outputName in $(getAllOutputNames); do
+          find "''${!outputName}" \( -name '*.dylib*' -o -name '*.so*' \)
+        done
+      )
+
+      # Determine the install_name_tool -change arguments that are going to be
+      # applied to all libraries.
+      change_args=()
+      for lib in "''${libraries[@]}"; do
+        lib_name="$(basename $lib)"
+        change_args+=(-change ../lib/$lib_name $lib)
+        change_args+=(-change ../../lib/$lib_name $lib)
       done
-    )
-
-    # Determine the install_name_tool -change arguments that are going to be
-    # applied to all libraries.
-    change_args=()
-    for lib in "''${libraries[@]}"; do
-      lib_name="$(basename $lib)"
-      change_args+=(-change ../lib/$lib_name $lib)
-      change_args+=(-change ../../lib/$lib_name $lib)
-    done
-
-    # Rewrite id and library refences for all non-symlinked libraries.
-    for lib in "''${libraries[@]}"; do
-      if [ -f "$lib" ]; then
-        install_name_tool -id $lib "''${change_args[@]}" $lib
-      fi
-    done
-
-    # Rewrite library references for all executables.
-    find "$out" -executable -type f | while read executable; do
-      install_name_tool "''${change_args[@]}" "$executable"
-    done
-  '';
+
+      # Rewrite id and library refences for all non-symlinked libraries.
+      for lib in "''${libraries[@]}"; do
+        if [ -f "$lib" ]; then
+          install_name_tool -id $lib "''${change_args[@]}" $lib
+        fi
+      done
+
+      # Rewrite library references for all executables.
+      find "$out" -executable -type f | while read executable; do
+        install_name_tool "''${change_args[@]}" "$executable"
+      done
+    '';
 
   # We need the libgcc_s.so.1 loadable (for pthread_cancel to work)
   dontPatchELF = true;
@@ -106,9 +129,7 @@ stdenv.mkDerivation (finalAttrs: {
     command = "pjsua --version";
   };
 
-  passthru.tests.pkg-config = testers.hasPkgConfigModules {
-    package = finalAttrs.finalPackage;
-  };
+  passthru.tests.pkg-config = testers.hasPkgConfigModules { package = finalAttrs.finalPackage; };
 
   passthru.tests.python-pjsua2 = runCommand "python-pjsua2" { } ''
     ${(python3.withPackages (pkgs: [ pkgs.pjsua2 ])).interpreter} -c "import pjsua2" > $out
@@ -121,8 +142,6 @@ stdenv.mkDerivation (finalAttrs: {
     maintainers = with maintainers; [ olynch ];
     mainProgram = "pjsua";
     platforms = platforms.linux ++ platforms.darwin;
-    pkgConfigModules = [
-      "libpjproject"
-    ];
+    pkgConfigModules = [ "libpjproject" ];
   };
 })